• Unveiling
     Kratom’s Alkaloids

  • Kratom leaves yield a diverse phytochemical profile—over 40 alkaloids, with 28
    extensively characterised for their pharmacology and safety." (MDPI Life)
Get Started →

What Is 7-OH?

7-OH, also known as 7-Hydroxymitragynine, is found in very small amounts in Kratom or Mitragyna speciosa. Unlike mitragynine, which is the most commonly found alkaloid, 7-OH is more potent, and it is the one compound that plays a role in how Kratom actually works. While it’s not as widely discussed, understanding 7-OH is essential to grasping how Kratom actually works.

Our Core Domains

Pharmacology Insights

Mechanistic reviews of receptor interactions—opioid, adrenergic and serotonergic pathways.

Read More
Regulatory Tracker

Real‑time monitoring of global scheduling, import alerts and dietary‑ingredient status.

Read More
Data Hub

Raw concentration datasets, certificates of analysis and methodological details for reproducibility.

Read More

Latest Research

7‑Hydroxymitragynine Mechanistic Study

7‑Hydroxymitragynine Mechanistic Study

7‑OH: A G protein‑biased μ‑opioid receptor agonist.

Learn More
NIH Pharmacokinetic Study

NIH Pharmacokinetic Study

Grant‑funded human absorption and elimination profiling.

Learn More
Global Regulation Survey

Global Regulation Survey

Comparative eight‑factor DEA review and FDA import alert impact.

Learn More
Open‑Access Data Release

Open‑Access Data Release

Certified batch analyses for 10 key alkaloids.

Learn More

Our Approach to Content Curation

We compile, synthesise and validate peer‑reviewed research, ensuring every entry reflects the highest informational standards:

Comprehensive Literature Review: Systematic searches across PubMed, MDPI, PMC and other scholarly databases.
Standardised Extraction: Uniform data‑capture templates to ensure consistency in chemical profiles, pharmacology metrics and safety notes.
Expert Oversight: Subject‑matter experts review all summaries for accuracy and clarity.

Curated Research Summaries

Explore our distilled insights from leading studies in six key areas:

Structural Characterisation

Summaries of high‑resolution NMR and MS findings, detailing the molecular structures of 28 alkaloids.
Pharmacological Profiles

Compilation of Ki and EC₅₀ values across µ, κ and δ opioid receptors, and notes on adrenergic and serotonergic interactions.
7‑Hydroxymitragynine (7‑OH) Deep Dive

Comprehensive analysis of 7‑OH’s nanomolar µ‑opioid receptor affinity (Ki ≈17 nM), G‑protein signalling bias and pharmacokinetic insights citeturn2file5.
Pharmacokinetics & Metabolism

Aggregated data on absorption (Tmax), elimination (T1/2) and major metabolites from human and in vivo studies.
Safety & Toxicology Reports

Overviews of clinical case series, in vitro cytotoxicity assays and documented adverse outcomes, with data tables for key endpoints.
Regulatory Landscape Analyses

Updated summaries of scheduling proposals, import alerts and dietary‑ingredient status across global jurisdictions.

Get Involved

We welcome contributions and collaborations to expand this resource:

Submit Your Data:

Upload concentration datasets or C of A reports for inclusion in our Data Hub.

Read More
Peer Review Network:

Volunteer to review new alkaloid monographs and pharmacology summaries.

Read More
Policy Forum:

Engage with regulators, clinicians and advocates in shaping evidence‑based guidelines.

Read More

FAQS

Frequently Asked Questions

Which is the most abundant?

Mitragynine—up to 66 % of total alkaloid content in dried leaves.

Are these compounds regulated?

They remain un‑scheduled internationally but face variable local restrictions and import alerts.

Can they cross the blood–brain barrier?

Yes, mitragynine and 7‑OH exhibit CNS penetration underpinning analgesic effects.