What Is 7-OH?
7-OH, also known as 7-Hydroxymitragynine, is found in very small amounts in Kratom or Mitragyna speciosa. Unlike mitragynine, which is the most commonly found alkaloid, 7-OH is more potent, and it is the one compound that plays a role in how Kratom actually works. While it’s not as widely discussed, understanding 7-OH is essential to grasping how Kratom actually works.
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Latest Research
7‑Hydroxymitragynine Mechanistic Study
7‑OH: A G protein‑biased μ‑opioid receptor agonist.
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Summaries of high‑resolution NMR and MS findings, detailing the molecular structures of 28 alkaloids.
Pharmacological Profiles
Compilation of Ki and EC₅₀ values across µ, κ and δ opioid receptors, and notes on adrenergic and serotonergic interactions.
7‑Hydroxymitragynine (7‑OH) Deep Dive
Comprehensive analysis of 7‑OH’s nanomolar µ‑opioid receptor affinity (Ki ≈17 nM), G‑protein signalling bias and pharmacokinetic insights citeturn2file5.
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Aggregated data on absorption (Tmax), elimination (T1/2) and major metabolites from human and in vivo studies.
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FAQS
Frequently Asked Questions
Which is the most abundant?
Which is the most abundant?
Mitragynine—up to 66 % of total alkaloid content in dried leaves.
Are these compounds regulated?
Are these compounds regulated?
They remain un‑scheduled internationally but face variable local restrictions and import alerts.
Can they cross the blood–brain barrier?
Can they cross the blood–brain barrier?
Yes, mitragynine and 7‑OH exhibit CNS penetration underpinning analgesic effects.