Biosynthesis & Stereochemistry
Summary: The C-20 stereocentre that distinguishes speciogynine (20R) from mitragynine (20S) is set by MsDCS1/2 and MsEnolMTin the kratom pathway. This directed route enables enzymatic production of either stereoisomer, clarifying how small stereochemical flips can re-wire pharmacology.
Key points:
Directed biosynthesis confirms speciogynine as the 20R epimer and provides tools to make stereochemically pure material for research.
